1173C>T Polymorphism in VKORC1 Modulates the Required Warfarin Dose

摘要: The response to warfarin is highly variable among individuals and such variability likely have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on Japanese, taking advantage its unique population structure in which CYP2C9 *2 *3 alleles are relatively rare. Thirty-one patients (12–34 years old; median, 22) were recruited from a pediatric cardiology clinic. Genotyping C>T polymorphism at position 1173 intron 1 revealed that 26 (84%) T/T homozygotes nucleotide 1173, whereas 5 (16%) C/T heterozygotes. Complete linkage disequilibrium was observed between 1173C > T another polymorphism, 3730G A, 3′ untranslated region. heterozyogtes tended require more than homozygotes, when adjusted for international normalized ratio (p = 0.003). Both A be inert functional standpoint. Rather, based complete polymorphisms, we suspect actual change defines relative resistance may present proximity these two polymorphisms.