TP53 Mutations and Pathologic Complete Response to Neoadjuvant Cisplatin and Fluorouracil Chemotherapy in Resected Oral Cavity Squamous Cell Carcinoma

摘要: Purpose To find out if TP53 functional status predicts response to neoadjuvant chemotherapy and thus may be helpful during treatment decision making of oral cavity squamous cell carcinoma (SCC) patients. Patients Methods We analyzed the predictive value mutations their on basis transactivation activity p53 mutant proteins in 53 pretreatment biopsies SCC patients receiving primary cisplatin fluorouracil followed by surgery. Results The surgical specimens showed that 15 (28%) achieved a pathologic complete remission (pCR) at both T N sites, 38 had residual tumor cells. Among biopsies, 24 (45%) displayed mutations: 22 single-nucleotide substitutions two deletions. According could determined only for substitutions, 21 were nonfunctional one was partially functional. mutation found four (27%) who achie...