Sequencing HNC: Emergence of notch signaling
作者： Curtis R. Pickering , Thomas J. Ow , Jeffrey N. Myers
DOI: 10.1007/978-1-4614-8815-6_15
关键词: Gene 、 Tumor suppressor gene 、 Head and neck cancer 、 Genomics 、 Bioinformatics 、 HRAS 、 CDKN2A 、 Notch signaling pathway 、 Biology 、 Suppressor
摘要: Head and neck cancer is driven by the accumulation of genomic abnormalities. Classically these were characterized chromosomal alterations TP53 mutations, but recent sequencing studies have improved our understanding full spectrum mutations in this disease. While a few oncogenes are found to be altered (PIK3CA, HRAS, CCND1), most frequent events inactivate tumor suppressor genes (TP53, CDKN2A). A surprising new finding was identification gene NOTCH1. These demonstrate that NOTCH1 an important head other squamous tumors. This has shed light on Notch pathway progression, clarified need learn more about progression biology cancer.
springer.com
utsystem.edu
elsevier.com参考文章(93)
Bram J. van Raam, Guy S. Salvesen, Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochimica et Biophysica Acta. ,vol. 1824, pp. 113- 122 ,(2012) , 10.1016/J.BBAPAP.2011.06.005
Yoshitsugu Mitani, Jie Li, Randal S. Weber, Scott L. Lippman, Elsa R. Flores, Carlos Caulin, Adel K. El-Naggar, Expression and Regulation of the ΔN and TAp63 Isoforms in Salivary Gland Tumorigenesis The American Journal of Pathology. ,vol. 179, pp. 391- 399 ,(2011) , 10.1016/J.AJPATH.2011.03.037
J C Ahomadegbe, G Riou, S Fogel, M Barrois, J P Armand, S Douc-Rasy, P Duvillard, M L Le Bihan, High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesions Oncogene. ,vol. 10, pp. 1217- 1227 ,(1995)
Cliff Tabin, Arlene Sharpe, Daniel Caput, Christopher Crum, Frank McKeon, Annie Yang, Ronen Schweitzer, Deqin Sun, Mourad Kaghad, Nancy Walker, Roderick T. Bronson, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature. ,vol. 398, pp. 714- 718 ,(1999) , 10.1038/19539
A. Hart, A. Balm, R. Michalides, E. Wientjens, B. Loftus, N. Van Veelen, Overexpression of Cyclin D1 Correlates with Recurrence in a Group of Forty-seven Operable Squamous Cell Carcinomas of the Head and Neck Cancer Research. ,vol. 55, pp. 975- 978 ,(1995)
Amy Young, Jesse Lyons, Abigail L. Miller, Vernon T. Phan, Irma Rangel Alarcón, Frank McCormick, Chapter 1 Ras Signaling and Therapies Advances in Cancer Research. ,vol. 102, pp. 1- 17 ,(2009) , 10.1016/S0065-230X(09)02001-6
Alea A. Mills, Binhai Zheng, Xiao-Jing Wang, Hannes Vogel, Dennis R. Roop, Allan Bradley, p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. ,vol. 398, pp. 708- 713 ,(1999) , 10.1038/19531
Kenji Okami, Li Wu, Greg Riggins, Paul Cairns, Michael Goggins, Ella Evron, Naomi Halachmi, Steven A Ahrendt, Andre L Reed, Werner Hilgers, Scott E Kern, Wayne M Koch, David Sidransky, Jin Jen, None, Analysis of PTEN/MMAC1 Alterations in Aerodigestive Tract Tumors Cancer Research. ,vol. 58, pp. 509- 511 ,(1998)
John A. Ridge, Dennis A. Carson, Andres J P Klein-Szanto, Edward R. Sauter, Shi Yu Zhang, Tsutomu Nobori, Shinichiro Mitsunaga, Marianna Shafarenko, Tamra L. Goodrow, Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck Cancer Research. ,vol. 54, pp. 5050- 5053 ,(1994)
Pedro Jares, Pedro L Fernández, Elías Campo, Alfons Nadal, Francesc Bosch, Gemma Aiza, Iracema Nayach, José Traserra, Antonio Cardesa, None, PRAD-1/cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Research. ,vol. 54, pp. 4813- 4817 ,(1994)