Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung

摘要: Filarial infections are tropical diseases caused by nematodes of the Onchocercidae family such as Mansonella perstans. The infective larvae (L3) transmitted into skin vertebrate hosts blood-feeding vectors. Many filarial species settle in serous cavities including M. perstans humans and L. sigmodontis, a well-established model filariasis mice. sigmodontis L3 migrate to pleural cavity where they moult L4 around day 9 male female adult worms 30. Little is known early phase parasite life cycle, after inoculated dermis vector enters afferent lymphatic vessels before moulting processes cavity. Here we reveal pulmonary associated with lung damage characterized haemorrhages granulomas suggesting reach via capillaries endothelium parenchyma crossing them enter This study also provides evidence for transient inflammation very recruitment neutrophils high expression levels S100A8 S100A9 proteins.