Myc target transcriptomes.

摘要: The c-Myc oncogenic transcription factor plays a central role in many human cancers through the regulation of gene expression. Although molecular mechanisms by which and its obligate partner, Max, regulate expression are becoming better defined, genes or transcriptomes that just emerging from variety different experimental approaches. Studies individual target their functional implications now complemented large surveys use subtraction cloning, DNA microarray analysis, serial analysis (SAGE), chromatin immunoprecipitation, genome marking methods. To fully appreciate differences between physiological function normal cells deregulated tumors, challenge is to determine how authenticated effect various phenotypes induced define altered Mad family proteins.