Neuropathic pain: mechanisms and their clinical implications

摘要: Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured neurons and along nociceptive descending modulatory pathways the central nervous system. The myriad neurotransmitters other substances involved development maintenance of neuropathic also play a part neurobiological disorders. This might partly explain high comorbidity rates for chronic pain, sleep disorders, psychological conditions such as depression, why drugs that are effective one condition may benefit others. be distinguished from non-neuropathic by two factors. Firstly, there is no transduction (conversion stimulus into an electrical impulse). Secondly, prognosis worse: injury to major nerves more likely than non-nervous tissue result pain. In addition, tends refractory conventional analgesics, non-steroidal anti-inflammatory opioids. However, because considerable overlap between terms mechanisms treatment modalities, it constructive view these entities different points on same continuum. review focuses with special emphasis clinical implications.