Traces of forgotten historical events in mountain communities in Central Italy: A genetic insight

摘要: Objectives Analysis of human genetic variation in mountain communities can shed light on the peopling mountainous regions, perhaps revealing whether remote geographic location spared them from outside invasion and preserved their gene pool admixture. In this study, we created a model to assess traces historical events by reconstructing paternal maternal history seven small villages inland valleys Central Italy. Methods The were selected for isolation, attested biodemographic stability, documented prior Roman conquest. We studied structure analyzing two hypervariable segments (HVS-I HVS-II) mtDNA D-loop several informative single nucleotide polymorphisms (SNPs) coding region 346 individuals, addition 17 short tandem repeats (STRs) Y-chromosome SNPs 237 male individuals. Results For both uniparental markers, most haplogroups originated Western Europe while some Near Eastern identified at low frequencies. However, there was an evident similarity between Italian samples populations mainly pool. Conclusions The highlight overall European pattern Y chromosome. Notwithstanding scenario, chromosome haplogroup Q, common lineage Central/Western Asia but almost Europe-wide absent, found, suggesting that Italy could have hosted settlement Anatolia might be supported cultural, topographic evidence. Am. J. Hum. Biol. 27:508–519, 2015. © 2015 Wiley Periodicals, Inc.