Linking between genetic structure and geographical distance: Study of the maternal gene pool in the Ethiopian population

摘要: Background The correlation between genetics and geographical distance has already been examined through the study of dispersion human populations, especially in terms uniparental genetic markers. Aim present work characterises, at level mitochondrial DNA (mtDNA), two new samples Amhara Oromo populations from Ethiopia to evaluate possible pattern distribution for mtDNA variation test hypothesis Isolation-by-Distance (IBD) model among African, European Middle-Eastern populations. Subjects methods This analysed 173 individuals belonging ethnic groups Ethiopia, Oromo, by assaying HVS-I HVS-II D-loop informative coding region SNPs mtDNA. Results analysis suggests a relationship geographic distances, affirming that pool Africa, Europe Middle East might be coherent with IBD model. Moreover, gene pools Sub-Saharan African Mediterranean were very different. Conclusion In this distribution, beginning Ethiopian plateau, was tested It could affirmed that, on continent scale, fall under