Primate models in serotonin transporter research

摘要: ABSTRACT Numerous studies provide persuasive evidence that a polymorphism in the serotonin promoter, 5-HTTLPR, interacts with environmental risk factors to produce heightened rates of depression, anxiety, antisocial and borderline personality disorders, substance abuse adults adolescents. Investigations rhesus monkey have demonstrated similar gene–environment (G×E) interactions on both behavioral biological outcomes. In this chapter, we review history primate models transporter (5-HTT) research. Work non-human primates has noted associations between differences variation metabolism (5-hydroxy-indole acetic acid, 5-HIAA). several species also indicated manipulation early experience results changes behavior along alterations serotonergic functioning. These lines research contributed discovery short ( s ) long l forms within promoter (rh5-HTTLPR) monkey. Researchers since documented / or genotypes reduced cognitive flexibility, greater impulsivity, anxious-like behavior, as well higher alcohol consumption. Furthermore, multiple G×E been for levels 5-HIAA, hypothalamic–pituitary–adrenocortical (HPA) axis activity, consumption, pathology, social play, aggression, infant temperament. most cases, these were due worse outcomes subjects had subjected maternal deprivation. This program demonstrates monkeys are more vulnerable effects early-life stress, whereas resilient.