Lymphopenia as a risk factor for neurologic involvement and organ damage accrual in patients with systemic lupus erythematosus: A multi-center observational study.

摘要: Abstract Objective Detailed analysis of hematological manifestations (HM) in systemic lupus erythematosus (SLE) are limited and their clinical impact on disease remain obscure. Here, we aimed to decipher factors associated with different abnormalities SLE patients assess related outcomes. Methods A dataset (GIPT) originating from six European tertiary centers was assessed. Six-monthly visits each patient for at least 2 years were registered. The association between hematologic (HM; per ACR-1997criteria) clinical/serologic variables, as well the HM outcomes (damage, infection hemorrhage) explored. Scores Systemic Lupus Erythematosus Disease Activity Index 2000(SLEDAI2K), International Collaborating Clinics (SLICC)/American College Rheumatology (ACR) Damage (SDI) events any hemorrhage recorded. Results compared a cross-sectional, well-characterized Sweden. Descriptive statistics, generalized estimating equations (GEE), general linear models (GLM), Cox regression applied. We monitored 1425 longitudinal 286 (GIPT dataset: 88% female, 95% Caucasian, 68% dsDNA positive). Thrombocytopenia (regression coefficient [95% confidence interval] 1.86[1.1–3.13]) neurologic involvement (ACR-8) (2.1[1.10–3.89]) lymphopenia ( Conclusion : Lymphopenia is independently organ damage accrual, thus, may be considered marker severe/progressive disease.