Improved mechanical properties of hydroxyapatite/poly(ɛ-caprolactone) scaffolds by surface modification of hydroxyapatite

作者: Yan Wang , Jing Dai , Qingchun Zhang , Yan Xiao , Meidong Lang

DOI: 10.1016/J.APSUSC.2010.03.127

关键词:

摘要: Abstract Scaffolds comprising hydroxyapatite (HAP) or poly(ɛ-caprolactone)-grafted (g-HAP) and poly(ɛ-caprolactone) (PCL) were prepared using the thermally induced phase separation/salt leaching technique. The g-HAP nanoparticles evaluated by Fourier Transformation Infrared Spectroscopy (FTIR) thermal gravimetric analysis (TGA). Power X-ray Diffraction (XRD) patterns confirmed successful grafting on surface of HAP. effects mechanical strength, porosity property scaffolds introduction extensively investigated. compressive modulus scaffold was greatly improved addition nanoparticles. Especially g-HAP/PCL containing 20 wt% 59.4% higher than that corresponding HAP/PCL scaffold.

参考文章(39)
Atsushi Matsuda, Tsutomu Furuzono, Dominic Walsh, Akio Kishida, Junzo Tanaka, Surface modification of a porous hydroxyapatite to promote bonded polymer coatings Journal of Materials Science: Materials in Medicine. ,vol. 14, pp. 973- 978 ,(2003) , 10.1023/A:1026302700149
Xiufeng Xiao, Rongfang Liu, Qiongyu Huang, Preparation and characterization of nano-hydroxyapatite/polymer composite scaffolds Journal of Materials Science: Materials in Medicine. ,vol. 19, pp. 3429- 3435 ,(2008) , 10.1007/S10856-008-3499-X
Young-Hag Koh, In-Kook Jun, Hyoun-Ee Kim, Fabrication of poly(ε-caprolactone)/hydroxyapatite scaffold using rapid direct deposition Materials Letters. ,vol. 60, pp. 1184- 1187 ,(2006) , 10.1016/J.MATLET.2005.10.103
Hong Jae Lee, Hyung Woo Choi, Kyung Ja Kim, Sang Cheon Lee, Modification of Hydroxyapatite Nanosurfaces for Enhanced Colloidal Stability and Improved Interfacial Adhesion in Nanocomposites Chemistry of Materials. ,vol. 18, pp. 5111- 5118 ,(2006) , 10.1021/CM061139X
F. Causa, P. A. Netti, L. Ambrosio, G. Ciapetti, N. Baldini, S. Pagani, D. Martini, A. Giunti, Poly-epsilon-caprolactone/hydroxyapatite composites for bone regeneration: in vitro characterization and human osteoblast response. Journal of Biomedical Materials Research Part A. ,vol. 76, pp. 151- 162 ,(2006) , 10.1002/JBM.A.30528
Xing-Hou Gong, Chak-Yin Tang, Hong-Chun Hu, Xing-Ping Zhou, Xiao-Lin Xie, Improved mechanical properties of HIPS/hydroxyapatite composites by surface modification of hydroxyapatite via in-situ polymerization of styrene. Journal of Materials Science: Materials in Medicine. ,vol. 15, pp. 1141- 1146 ,(2004) , 10.1023/B:JMSM.0000046397.09060.15
G. Ciapetti, L. Ambrosio, L. Savarino, D. Granchi, E. Cenni, N. Baldini, S. Pagani, S. Guizzardi, F. Causa, A. Giunti, Osteoblast growth and function in porous poly ε-caprolactone matrices for bone repair: a preliminary study Biomaterials. ,vol. 24, pp. 3815- 3824 ,(2003) , 10.1016/S0142-9612(03)00263-1
S.A.M. Ali, S.-P. Zhong, P.J. Doherty, D.F. Williams, Mechanisms of polymer degradation in implantable devices. I. Poly(caprolactone). Biomaterials. ,vol. 14, pp. 648- 656 ,(1993) , 10.1016/0142-9612(93)90063-8