Poly(α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology
作者： Ruiyun Zhang , Peter X. Ma
DOI: 10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F
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摘要: Tissue engineering has shown great promise for creating biological alternatives implants. In this approach, scaffolding plays a pivotal role. Hydroxyapatite mimics the natural bone mineral and good bone-bonding properties. This paper describes preparation morphologies of three-dimensional porous composites from poly(L-lactic acid) (PLLA) or poly(D,L-lactic acid-co-glycolic (PLGA) solution hydroxyapatite (HAP). A thermally induced phase separation technique was used to create highly composite scaffolds bone-tissue engineering. Freeze drying phase-separated polymer/HAP/solvent mixtures produced hard tough foams with co-continuous structure interconnected pores polymer/HAP skeleton. The microstructure walls controlled by varying polymer concentration, HAP content, quenching temperature, polymer, solvent utilized. porosity increased decreasing concentration content. Foams as high 95% were achieved. Pore sizes ranging several microns few hundred obtained. showed significant improvement in mechanical properties over pure foams. They are promising
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