Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan

摘要: Recent studies relating to the association between DNA repair-gene polymorphisms and colorectal cancer risk would, best of our knowledge, appear be very limited. This study was designed examine associated with three repair genes, namely: XRCC1 Arg399Gln, XRCC3 Thr241Met XPD Lys751Gln, investigate their role as susceptibility markers for cancer. We conducted a case-control including 727 cases 736 hospital-based age- sex-matched healthy controls genetic DNA-repair genes (XRCC1, XPD) in context Taiwanese population. Genomic isolated from 10 ml whole blood used genotype Lys751Gln by means polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) analysis. The did not differ significantly amongst individuals featuring 399Arg/Arg (OR = 1.18; 95% CI, 0.96–1.45), 241Thr/Thr 1.25; 0.88–1.79) or 751Gln allele 1.20; 0.90–1.61), although greater number genotypes (genotype OR than 1) experience higher when compared those who didn't feature any (Trend test P 0.03). Compared express putative genotypes, all 2.43, CI 1.21–4.90), particularly suffering tumors located rectum 3.18, 1.29–7.82) diagnosed prior age 60 years 4.90, 1.72–14.0). Our results suggest that pathways may simultaneously modulate population, and, rectal younger patients.