Polymorphisms in DNA repair genes and associations with cancer risk.

摘要: Common polymorphisms in DNA repair genes may alter protein function and an individual’s capacity to damaged DNA; deficits lead genetic instability carcinogenesis. To establish our overall understanding of possible vivo relationships between the development cancer, we performed a literature review epidemiological studies that assessed associations such risk cancer. Thirty OGG1 , XRCC1 ERCC1 XPC XPD XPF BRCA2 XRCC3 were identified April 30, 2002 MEDLINE database (National Center for Biotechnology Information. PubMed Database: http://www.ncbi.nlm.nih.gov/entrez). These focused on adult glioma, bladder breast esophageal lung prostate skin cancer (melanoma nonmelanoma), squamous cell carcinoma head neck, stomach We found small proportion published large population-based. Nonetheless, data consistent with between: ( ) S326C variant increased various types cancer; b R194W reduced c N372H Suggestive results seen other genes; however, sample sizes have contributed false-positive or false-negative findings. conclude large, well-designed common are needed. Such benefit from analysis multiple consideration relevant exposures influence likelihood presence capacity.