cj0371: A Novel Virulence-Associated Gene of Campylobacter jejuni.
作者： Xueqing Du , Nan Wang , Fangzhe Ren , Hong Tang , Xinan Jiao
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摘要: Campylobacter jejuni is the major cause of human bacterial diarrhea worldwide. Its pathogenic mechanism remains poorly understood. cj0371 a novel gene that was uncovered using immunoscreening. There have been no previous reports regarding its function. In this study, we constructed an insertion mutant and complement in C. examined changes virulence. We observed showed significantly increased invasion colonization ability. also investigated role motility, chemotaxis growth kinetics to further study found displays hypermotility, enhanced kinetics. addition, localized Cj0371 protein at poles by fluorescence microscopy. present data collectively proves our hypothesis new virulence-associated through influence plays negative pathogenicity.
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