New developments in the diagnosis and treatment of axial spondyloarthritis

作者: Pedro Machado , Robert Landewé , Désirée van der Heijde

DOI: 10.4155/CLI.12.148

关键词:

摘要: Spondyloarthritis (SpA) is an umbrella term for a group of diseases sharing genetic, molecular, immunological, clinical and imaging features. The last few years have witnessed remarkable progress in the understanding SpA. Notable advances include recognition MRI as sensitive specific tool detecting axial inflammation recent development validation Assessment International Society classification criteria predominantly peripheral This approach has advantage better describing disease, allowing earlier identification treatment non-radiographic forms potentially leading to improved outcomes. TNF α-blockers, which dramatically improve symptoms signs patients with ankylosing spondylitis, are now being tested SpA, first studies providing evidence that form disease also benefit from this...

参考文章(136)
D�sir�e van der Heijde, Ben Dijkmans, Piet Geusens, Joachim Sieper, Kimberly DeWoody, Paul Williamson, J�rgen Braun, , Efficacy and safety of infliximab in patients with ankylosing spondylitis: results of a randomized, placebo-controlled trial (ASSERT). Arthritis & Rheumatism. ,vol. 52, pp. 582- 591 ,(2005) , 10.1002/ART.20852
N. J Sheehan, The ramifications of HLA-B27. Journal of the Royal Society of Medicine. ,vol. 97, pp. 10- 14 ,(2004) , 10.1258/JRSM.97.1.10
Georg Schett, Martin Rudwaleit, None, Can we stop progression of ankylosing spondylitis Best Practice & Research: Clinical Rheumatology. ,vol. 24, pp. 363- 371 ,(2010) , 10.1016/J.BERH.2010.01.005
Astrid van Tubergen, Sofia Ramiro, Désirée van der Heijde, Maxime Dougados, Herman Mielants, Robert Landewé, Development of new syndesmophytes and bridges in ankylosing spondylitis and their predictors: a longitudinal study Annals of the Rheumatic Diseases. ,vol. 71, pp. 518- 523 ,(2012) , 10.1136/ANNRHEUMDIS-2011-200411
D Van der Heijde, R Landewe, S Einstein, P Ory, D Vosse, L Ni, S‐L Lin, W Tsuji, JC Davis Jr, None, Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis & Rheumatism. ,vol. 58, pp. 1324- 1331 ,(2008) , 10.1002/ART.23471
Robert D. Inman, John C. Davis, Désirée Van Der Heijde, Laura Diekman, Joachim Sieper, Sung Il Kim, Michael Mack, John Han, Sudha Visvanathan, Zhenhua Xu, Benjamin Hsu, Anna Beutler, Jürgen Braun, Efficacy and safety of golimumab in patients with ankylosing spondylitis: results of a randomized, double-blind, placebo-controlled, phase III trial. Arthritis & Rheumatism. ,vol. 58, pp. 3402- 3412 ,(2008) , 10.1002/ART.23969
K. M. Fagerli, E. Lie, D. van der Heijde, M. S. Heiberg, C. Kaufmann, E. Rodevand, K. Mikkelsen, S. Kalstad, T. K. Kvien, Selecting patients with ankylosing spondylitis for TNF inhibitor therapy: comparison of ASDAS and BASDAI eligibility criteria Rheumatology. ,vol. 51, pp. 1479- 1483 ,(2012) , 10.1093/RHEUMATOLOGY/KES057
Ejaz Pathan, Sonya Abraham, Elizabeth Van Rossen, Robin Withrington, Andrew Keat, Peter J Charles, Erin Paterson, Muslima Chowdhury, Catherine McClinton, Peter C Taylor, Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in ankylosing spondylitis Annals of the Rheumatic Diseases. ,vol. 72, pp. 1475- 1480 ,(2013) , 10.1136/ANNRHEUMDIS-2012-201915
S. J. Pedersen, I. J. Sorensen, P. Garnero, J. S. Johansen, O. R. Madsen, N. Tvede, M. S. Hansen, G. Thamsborg, L. S. Andersen, O. Majgaard, A. G. Loft, J. Erlendsson, K. Asmussen, A. G. Jurik, J. Moller, M. Hasselquist, D. Mikkelsen, T. Skjodt, R. Lambert, A. Hansen, M. Ostergaard, ASDAS, BASDAI and different treatment responses and their relation to biomarkers of inflammation, cartilage and bone turnover in patients with axial spondyloarthritis treated with TNFα inhibitors Annals of the Rheumatic Diseases. ,vol. 70, pp. 1375- 1381 ,(2011) , 10.1136/ARD.2010.138883
P. Machado, R. Landewe, J. Braun, K.-G. A. Hermann, D. Baker, D. van der Heijde, Both structural damage and inflammation of the spine contribute to impairment of spinal mobility in patients with ankylosing spondylitis Annals of the Rheumatic Diseases. ,vol. 69, pp. 1465- 1470 ,(2010) , 10.1136/ARD.2009.124206