Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination.
作者： S A Tasduq , K Singh , N K Satti , D K Gupta , K A Suri
DOI: 10.1191/0960327106HT601OA
关键词:
摘要: Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. (fruit) (TC extract), which was chemically characterized on basis chebuloside II as marker, investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC found to prevent hepatotoxicity caused by administration rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) sub-chronic mode (12 weeks). The effect could be attributed its prominent anti-oxidative membrane stabilizing activities. changes biochemical observations were supported histological profile.
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sci-hub.se 参考文章(26)
R.L. Post, A.K. Sen, [116] Sodium and potassium-stimulated ATPase Methods in Enzymology. ,vol. 10, pp. 762- 768 ,(1967) , 10.1016/0076-6879(67)10125-0
Tamhane, SA Dahanukar, SP Thorat, NN Rege, Effect of oral administration of Terminalia chebula on gastric emptying: an experimental study. Journal of Postgraduate Medicine. ,vol. 43, pp. 12- ,(1997)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
A. Vonshak, O. Barazani, P. Sathiyamoorthy, R. Shalev, D. Vardy, A. Golan-Goldhirsh, Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytotherapy Research. ,vol. 17, pp. 1123- 1125 ,(2003) , 10.1002/PTR.1399
Mi-Jeong Ahn, Chul Young Kim, Ji Suk Lee, Tae Gyun Kim, Seung Hee Kim, Chong-Kyo Lee, Bo-Bin Lee, Cha-Gyun Shin, Hoon Huh, Jinwoong Kim, Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis. Planta Medica. ,vol. 68, pp. 457- 459 ,(2002) , 10.1055/S-2002-32070
M. MOURELLE, P. MURIEL, L. FAVARI, T. FRANCO, PREVENTION OF CCL4-INDUCED LIVER CIRRHOSIS BY SILYMARIN Fundamental & Clinical Pharmacology. ,vol. 3, pp. 183- 191 ,(1989) , 10.1111/J.1472-8206.1989.TB00449.X
L Garza-Ocañas, M.T Zanatta-Calderón, D Acosta, O Torres-Alanı́s, A Piñeyro-López, Production of reactive oxygen species by toxin T-514 of genus Karwinskia in vitro. Toxicology in Vitro. ,vol. 17, pp. 19- 25 ,(2003) , 10.1016/S0887-2333(02)00126-1
S TASDUQ, K PEERZADA, S KOUL, R BHAT, R JOHRI, Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin. Hepatology Research. ,vol. 31, pp. 132- 135 ,(2005) , 10.1016/J.HEPRES.2005.01.005
M.P. Germanò, V. D’Angelo, R. Sanogo, S. Catania, R. Alma, R. De Pasquale, G. Bisignano, Hepatoprotective and antibacterial effects of extracts from Trichilia emetica Vahl. (Meliaceae). Journal of Ethnopharmacology. ,vol. 96, pp. 227- 232 ,(2005) , 10.1016/J.JEP.2004.09.011
R.K. Reen, M. Karan, Kuldip Singh, V. Karan, R.K. Johri, Jaswant Singh, Screening of various Swertia species extracts in primary monolayer cultures of rat hepatocytes against carbon tetrachloride- and paracetamol-induced toxicity Journal of Ethnopharmacology. ,vol. 75, pp. 239- 247 ,(2001) , 10.1016/S0378-8741(01)00191-X