Targeting the Apoptotic Machinery as a Potential Antileukemic Strategy

摘要: Apoptosis is a morphologically and biochemically distinctive cell death process that occurs under several physiologic pathologic conditions (1,2). Morphologically, apoptosis characterized by plasma membrane blebbing followed chromatin condensation disassembly of the into multiple membrane-enclosed fragments, which are then engulfed neighboring cells or professional phagocytes (2). These biochemical changes believed to reflect, at least in part, action caspases, unique intracellular proteases digest critical polypeptides required for cellular integrity survival (3,4).