The rate of false-positive diagnosis of colorectal liver metastases in patients undergoing resection with the development of a novel, externally validated risk score

摘要: Background Diagnostic error in patients undergoing resection of colorectal liver metastases (CRLM) is unusual but exposes to unnecessary risks associated with treatment. The primary aim this study was determine the rate and risk factors for a false-positive diagnosis hepatic resection. secondary develop validate score predict diagnosis. Methods Patients were identified from prospectively maintained databases. who underwent first presumed divided into 2 groups: CRLMPOS (colorectal present on histology or appearance complete pathologic response preoperative chemotherapy) CRLMNEG (all others). Univariable analysis multivariable binary logistic regression used identify CRLMNEG. Risk scores developed both without use carcinoembryonic antigen validated an external cohort. Results 3.1% test validation cohorts (39/1,252 59/1,900, respectively). had fewer (P = .006) smaller lesions (P Conclusion A affected same proportion unrelated cohorts. This development novel supported by validation.