Regulation of integrin-mediated adhesions.

摘要: Integrins are heterodimeric transmembrane adhesion receptors that couple the actin cytoskeleton to extracellular environment and bidirectionally relay signals across cell membrane. These processes critical for attachment, migration, differentiation, survival, therefore play essential roles in metazoan development, physiology, pathology. Integrin-mediated adhesions regulated by diverse factors, including conformation-specific affinities of integrin their ligands, clustering integrins intracellular binding partners into discrete adhesive structures, mechanical forces exerted on adhesion, trafficking themselves. Recent advances shed light onto how interaction specific proteins with short cytoplasmic tails controls each these activities.