Morphological alterations in amygdalo-hippocampal substructures in narcolepsy patients with cataplexy

摘要: Although the role of hypocretin-mediated amygdalo-hippocampal dysfunction is hypothesized to be linked with narcolepsy, there have been no human MRI studies investigating relationship between their regional volume and key symptoms narcolepsy. To investigate morphological changes amygdalo-hippocampus its clinical features in patients point-wise morphometry that allowed for measuring volumes on T1-weighted was applied. Participants were 33 drug-naive 35 age-/gender-matched controls (mean ± SD: 27 ± 6 years). We compared hippocampal amygdalar subfields correlated neuropsychological patients. Bilateral atrophy (183 vertices) identified mainly located within CA1 subfield (FDR  0.2). After controlling depressive mood, sleep quality, age, gender, centromedial associated longer duration daytime sleepiness shorter mean REM latency (|r| >0.44, p  0.47, p < 0.005). Subfields untreated narcolepsy found relative suggests hippocampus area amygdala are closely related severity play a crucial circuitry cataplexy.