Omega-3 fatty-acids modulate symptoms of depressive disorder, serum levels of omega-3 fatty acids and omega-6/omega-3 ratio in children. A randomized, double-blind and controlled trial
作者： Jana Trebatická , Zuzana Hradečná , Anna Surovcová , Barbora Katrenčíková , Irina Gushina
DOI: 10.1016/J.PSYCHRES.2020.112911
关键词:
摘要: Abstract Omega-3 fatty acids (FA) are a promising adjuvant therapy for depressive disorder (DD) in adults. The objective of this single-centre, randomized, double-blind and controlled study was to compare the efficacy an omega-3 FA fish oil emulsion with control alongside standard treatment depression children adolescents suffering from DD or mixed anxiety (MADD) analyse serum acid levels omega-6/omega-3 ratio before after intervention. 60 were randomised 1:1 intervention (Om3) active comparator (Om6) groups. Children's Depression Inventory (CDI) ratings performed at baseline, every 2 weeks 12-week period. Significant reductions CDI scores observed after 6 12 Om3 group DD subgroup compared Om6 MADD subgroup. Ratio decreased but not 24.2/1 7.6/1 weeks, EPA, ratio, DHA, correlated severity symptoms baseline. An rich may be effective supplement during treatment disorders children. Trial registration: ISRCTN 81655012
sci-hub.se 参考文章(61)
Victor M. Montori, Nina V. Kraguljac, High S. Chai, Mani Pavuluri, Sencan S. Unal, Brian S. Wilson, Efficacy of omega-3 fatty acids in mood disorders - A systematic review and metaanalysis Psychopharmacology Bulletin. ,vol. 42, pp. 39- 54 ,(2009)
Serena Counsell, BK Puri, AJ Richardson, DF Horrobin, G Hamilton, Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. International Journal of Clinical Practice. ,vol. 55, pp. 560- 563 ,(2001)
Kate L Jansen, Molly S Clark, J Anthony Cloy, Treatment of childhood and adolescent depression. American Family Physician. ,vol. 86, pp. 442- 448 ,(2012)
Magdaléna Vaváková, Zdeňka Ďuračková, Jana Trebatická, Markers of Oxidative Stress and Neuroprogression in Depression Disorder Oxidative Medicine and Cellular Longevity. ,vol. 2015, pp. 898393- 898393 ,(2015) , 10.1155/2015/898393
Xiao-hui Qiu, Tian Xue, Jia-run Yang, Han Dong, Qiao Zheng-Xue, Dong Qi, Combined application of eicosapentaenoic acid and docosahexaenoic acid on depression in women: a meta-analysis of double-blind randomized controlled trials Neuropsychiatric Disease and Treatment. ,vol. 11, pp. 2055- 2061 ,(2015) , 10.2147/NDT.S86581
A.P Simopoulos, The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy. ,vol. 56, pp. 365- 379 ,(2002) , 10.1016/S0753-3322(02)00253-6
Adrian L. Lopresti, Sean D. Hood, Peter D. Drummond, A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise Journal of Affective Disorders. ,vol. 148, pp. 12- 27 ,(2013) , 10.1016/J.JAD.2013.01.014
J G Martins, H Bentsen, B K Puri, Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis Molecular Psychiatry. ,vol. 17, pp. 1144- 1149 ,(2012) , 10.1038/MP.2012.25
Robert K. McNamara, Jennifer Strimpfel, Ronald Jandacek, Therese Rider, Patrick Tso, Jeffrey A. Welge, Jeffrey R. Strawn, Melissa P. DelBello, Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder. PharmaNutrition. ,vol. 2, pp. 38- 46 ,(2014) , 10.1016/J.PHANU.2014.02.002
Marlene P. Freeman, Joseph R. Hibbeln, Katherine L. Wisner, John M. Davis, David Mischoulon, Malcolm Peet, Paul E. Keck, Lauren B. Marangell, Alexandra J. Richardson, James Lake, Andrew L. Stoll, Omega-3 fatty acids: Evidence basis for treatment and future research in psychiatry The Journal of Clinical Psychiatry. ,vol. 67, pp. 1954- 1967 ,(2006) , 10.4088/JCP.V67N1217