Combined application of eicosapentaenoic acid and docosahexaenoic acid on depression in women: a meta-analysis of double-blind randomized controlled trials

作者: Xiao-hui Qiu , Tian Xue , Jia-run Yang , Han Dong , Qiao Zheng-Xue

DOI: 10.2147/NDT.S86581

关键词: MedicineRandomized controlled trialDocosahexaenoic acidPolyunsaturated fatty acidPlaceboMeta-analysisDepression (differential diagnoses)Internal medicineEicosapentaenoic acidDouble blind

摘要: Objectives Previous randomized controlled trials (RCTs) suggest that depression can be effectively treated by omega-3 polyunsaturated fatty acids (PUFAs). Therefore, we conducted this meta-analysis to systematically evaluate the clinical applicability of combination docosahexaenoic acid (DHA) and eicosapentaenoic (EPA), which are two major bioactive types PUFAs, in depressed women. Methods RCTs compared DHA EPA placebo for short-course treatment women were reviewed up March 2015. Outcome measurement was standardized difference means measure severity. Random effect model performed. Meta-regression analysis performed assess effects baseline scores. Results Data obtained from eight RCTs. In these RCTs, 182 patients received 185 EPA. The pooled mean 0.65 with 95% CI = [0.18, 1.12]. There no relation between efficacy sensitivity found as monotherapy yielded a (95% =0.41, 0.90) without heterogeneity. Discussion These results indicate beneficial on mood placebo. showed greater promise should further explored.

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