Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.

摘要: The susceptibility of newborn mice to the inception tolerance after exposure antigen is associated with their deficiency in production endogenous interleukin 2 (IL-2). As further evidence complicity IL-2 and maintenance tolerance, it shown here that a solid long-lasting state induced by intravenous injection into CBA lymphoid cells from (CBA X C57BL/10ScSn)F1 hybrids can be brought an end administration exogenous or supplementing otherwise normal diet vitamin A acetate, effect which increase proportion moiety T-cell population produces IL-2. These results indicate certain nonspecific stimuli influence whether immunological maintained.