Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor
作者： Axel Gossmann , Thomas H. Helbich , Sam Mesiano , David M. Shames , Michael F. Wendland
关键词:
摘要: Objective: Magnetic resonance imaging enhanced with macromolecular contrast medium was used to monitor effects of angiogenesis inhibition on tumor microvascular permeability and ascites volume in an athymic rat model human ovarian cancer. Study Design: Groups 6 rats implanted intraperitoneally SKOV-3, a cancer cell line, were treated through 14-day course antibody vascular endothelial growth factor or saline solution for control animals. Dynamic magnetic performed 92,000-d agent, albumin-(gadolinium-diethylenetriaminepentaacetic acid)30. Vascular estimated from dynamic enhancement data that analyzed unidirectional 2-compartment kinetic model. Results: Animals accumulated significantly smaller volumes peritoneal (P < .05) showed lower imaging–assayed permeabilities than did Conclusion: agent anti–vascular can be measure reduction permeability, corresponding production. (Am J Obstet Gynecol 2000;183:956-63.)
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