Novel porphyrin–Schiff base conjugates: synthesis, characterization and in vitro photodynamic activities
作者： Ya-Hong Yao , Jun Li , Long-Fei Yuan , Zeng-Qi Zhang , Feng-Xing Zhang
DOI: 10.1039/C6RA05682B
关键词:
摘要: Three novel porphyrin–Schiff base conjugates derived from tetra(4-aminophenyl)porphyrin (TAPP), namely, tetra[4-(4-hydroxy benzylideneamino)]phenyl porphyrin (3a), tetra[4-(2-thienyldeneamino)]phenyl (3b) and tetra[4-(2-pyridyldeneamino)]phenyl (3c), were synthesized characterized by IR, UV-vis, 1H NMR, HRMS elementary analysis. Their biological activities against human epidermoid carcinoma (A431) cells evaluated with an MTT assay. As we expected, the showed negligible cytotoxicity to A431 in absence of light, while their phototoxic improved after irradiated LED lamp (425 nm) increased significantly doses. The fluorescence microscope pictures revealed that three could diffuse into skin cancer cells, demonstrating these compounds are potential candidates for photodynamic therapy agents.
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