Neuromagnetic Cerebellar Activity Entrains to the Kinematics of Executed Finger Movements.

摘要: This magnetoencephalography (MEG) study aims at characterizing the coupling between cerebellar activity and kinematics of repetitive self-paced finger movements. Neuromagnetic signals were recorded in 11 right-handed healthy adults while they performed flexion–extensions right-hand fingers three different movement rates: slow (~ 1 Hz), medium (~ 2 Hz), fast (~ 3 Hz). Right index acceleration was monitored with an accelerometer. Coherence analysis used to right neuromagnetic signals. Dynamic imaging coherent sources locate sources. Coupling directionality primary sensorimotor (SM1), cerebellar, accelerometer assessed renormalized partial directed coherence. Permutation-based statistics coupled maximum statistic over entire brain volume or restricted cerebellum used. At all rates, coherence peaked SM1 cortex contralateral movements frequency (F0) its first harmonic (F1). Significant (statistics cerebellum) consistently posterior lobe F0 no influence rate. Acc significantly stronger afferent than efferent direction effective contribution cortico-cerebellar cerebello-cortical pathways. demonstrates existence significant ipsilateral F0. is mainly driven by spinocerebellar, presumably proprioceptive, afferences.