Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo
作者： Konstantinos Anagnostakos , Philippe Wilmes , Eduard Schmitt , Jens Kelm
DOI: 10.3109/17453670902884700
关键词:
摘要: Background and purpose Late infections after total hip arthroplasty are still a problem. Treatment procedures include resection with implantation of antibiotic-loaded beads or an antibiotic-impreganted spacer. However, little is known about antibiotic elution from bone cement beyond the first 2–3 postoperative days in humans.Methods 17 spacers (80g PMMA, 1g gentamicin, 4 g vancomycin) 11 chains (40 0.5 2 28 patients were studied. The release both agents was measured drainage fluid on daily basis. drains left situ until less than 50 mL produced per day. antibiotics determined by fluorescence polarization immunoassay. Systemic given postoperatively according to antibiogram. If possible, no gentamicin vancomycin given.Results Peak mean concentrations reached for (1,160 (12–371) µg/mL 21 (0.7–39) µg/mL, respec...
informahealthcare.com参考文章(21)
John Klekamp, John M. Dawson, David W. Haas, David DeBoer, Michael Christie, The use of vancomycin and tobramycin in acrylic bone cement: biomechanical effects and elution kinetics for use in joint arthroplasty. Journal of Arthroplasty. ,vol. 14, pp. 339- 346 ,(1999) , 10.1016/S0883-5403(99)90061-X
Bassam A. Masri, Clive P. Duncan, Christopher P. Beauchamp, Long-term Elution of Antibiotics from Bone-Cement An in vivo Study Using the Prosthesis of Antibiotic-loaded Acrylic Cement (PROSTALAC) System Journal of Arthroplasty. ,vol. 13, pp. 331- 338 ,(1998) , 10.1016/S0883-5403(98)90179-6
PANG-HSIN HSIEH, CHUN-HSIUNG SHIH, YU-HAN CHANG, MEL S. LEE, HSIN-NUNG SHIH, WEN-E YANG, Two-stage revision hip arthroplasty for infection: comparison between the interim use of antibiotic-loaded cement beads and a spacer prosthesis. Journal of Bone and Joint Surgery, American Volume. ,vol. 86, pp. 1989- 1997 ,(2004) , 10.2106/00004623-200409000-00018
Konstantinos Anagnostakos, Jens Kelm, Thilo Regitz, Eduard Schmitt, Werner Jung, In vitro evaluation of antibiotic release from and bacteria growth inhibition by antibiotic-loaded acrylic bone cement spacers Journal of Biomedical Materials Research Part B. ,vol. 72, pp. 373- 378 ,(2005) , 10.1002/JBM.B.30171
Allan J. McLean, Lisa L. IoannidesDemos, Shu C. Li, Elisa B. Bastone, W. John Spicer, Bactericidal effect of gentamicin peak concentration provides a rationale for administration of bolus doses Journal of Antimicrobial Chemotherapy. ,vol. 32, pp. 301- 305 ,(1993) , 10.1093/JAC/32.2.301
M. Chohfi, F. Langlais, J. Fourastier, J. Minet, H. Thomazeau, M. Cormier, Pharmacokinetics, uses, and limitations of vancomycin-loaded bone cement. International Orthopaedics. ,vol. 22, pp. 171- 177 ,(1998) , 10.1007/S002640050235
Pang-Hsin Hsieh, Yu-Han Chang, Shih-Hao Chen, Steve W.N. Ueng, Chun-Hsiung Shih, High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days. Journal of Orthopaedic Research. ,vol. 24, pp. 1615- 1621 ,(2006) , 10.1002/JOR.20214
KENNETH ADAMS, LESLIE COUCH, GEORGE CIERNY, JASON CALHOUN, JON T. MADER, In vitro and in vivo evaluation of antibiotic diffusion from antibiotic-impregnated polymethylmethacrylate beads. Clinical Orthopaedics and Related Research. ,vol. 278, pp. 244- 252 ,(1992) , 10.1097/00003086-199205000-00037
EDUARDO A. SALVATI, JOHN J. CALLAGHAN, BARRY D. BRAUSE, RENATA F. KLEIN, ROBERT D. SMALL, Reimplantation in infection. Elution of gentamicin from cement and beads. Clinical Orthopaedics and Related Research. pp. 83- 93 ,(1986) , 10.1097/00003086-198606000-00015
Murray J. Penner, Basam A. Masri, Clive P. Duncan, Elution Characteristics of Vancomycin and Tobramycin Combined in Acrylic Bone-Cement Journal of Arthroplasty. ,vol. 11, pp. 939- 944 ,(1996) , 10.1016/S0883-5403(96)80135-5