Elution Characteristics of Vancomycin and Tobramycin Combined in Acrylic Bone-Cement
作者： Murray J. Penner , Basam A. Masri , Clive P. Duncan
DOI: 10.1016/S0883-5403(96)80135-5
关键词:
摘要: Combining two antibiotics in antibiotic-loaded bone-cement is common clinical practice. As the effect this has on elution characteristics unknown, an vitro quantitative study was carried out. Three groups of five cement disks were prepared and placed individual saline baths for 5 weeks. The tobramycin from group (containing 2.4 g 1.0 vancomycin per 40-g packet Palacos-R powder [Smith & Nephew Orthopaedics, Memphis, TN]) increased by 68% over that control (2.4 only) (P = .024). release 103% (1.0 .007). improves both may translate into enhanced vivo.
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