Vancomycin vs tobramycin elution from polymethylmethacrylate: an in vitro study.

摘要: We fabricated batches of cement containing 0.5 gm, 1.0 and 2.0 gm vancomycin one with tobramycin shaped them into cylinders. They were immersed L normal saline the fluid volume was changed daily. Samples obtained on days 1, 2, 3, 5, 7, 14, 28. All samples had antibiotic assays performed to quantitate amount elution for or tobramycin. Vancomycin from PMMA occurred under our study conditions in similar quantities that measured controls. Vancomycin-loaded may have a clinical role treatment musculoskeletal sepsis caused by gram-positive bacteria, particularly if organisms resistant usual agents are identified.