Regional cortical thickness in relapsing remitting multiple sclerosis: A multi-center study.
作者： Ponnada A Narayana , Koushik A Govindarajan , Priya Goel , Sushmita Datta , John A Lincoln
DOI: 10.1016/J.NICL.2012.11.009
关键词:
摘要: A comprehensive analysis of the global and regional values cortical thickness based on 3D magnetic resonance images was performed 250 relapsing remitting multiple sclerosis (MS) patients who participated in a multi-center, randomized, phase III clinical trial (the CombiRx Trial) 125 normal controls. The MS cohort characterized by relatively low disability short disease duration. An automatic pipeline developed for identifying with poor quality artifacts. thicknesses were determined using FreeSurfer software. Our results indicate significant thinning regions patient relative to Both more prominent left hemisphere right hemisphere. Modest correlation observed between measures that included extended status scale also T1-hypointense T2-hyperintense lesions. These correlations very similar at 1.5 T 3 T field strengths. much weaker inverse age among subjects compared This age-dependent stronger males than females. However, changes both be 1.5 T.
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