The phospholipase A2 inhibitor methyl indoxam suppresses diet‐induced obesity and glucose intolerance in mice

摘要: Background and purpose:  Previous results have shown that mice lacking in the group 1B phospholipase A2 (Pla2g1b) are resistant to obesity diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. This study examined potential of using Pla2g1b inhibitor methyl indoxam as therapy suppress diet-induced diabetes. Experimental approach:  Male C57BL/6 were fed diet with or without supplementation. Body weight gain, fasting plasma glucose levels, tolerance postprandial lysophospholipid absorption compared. Key results:  Wild-type showed 31 69% body gain after 4 10 weeks respectively. These animals also elevated levels intolerant. In contrast, 90 mg·kg−1 gained only 5% weeks. euglycaemic displayed normal excursion rates test. Methyl suppression intolerance was correlated inhibition Pla2g1b-mediated absorption. Conclusions implications:  show oral supplementation effectively suppresses mice. suggests may be potentially effective therapeutic option for treatment diabetes.