Group 1B phospholipase A2 inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice
作者： Norris I. Hollie , Eddy S. Konaniah , Colleen Goodin , David Y. Hui
DOI: 10.1016/J.ATHEROSCLEROSIS.2014.03.027
关键词:
摘要: Objective Previous studies have shown that inactivation of the group 1B phospholipase A2 (Pla2g1b) suppresses diet-induced obesity, hyperglycemia, insulin resistance, and hyperlipidemia in C57BL/6 mice. A possible influence Pla2g1b on atherosclerosis has not been addressed previously. The current study utilized LDL receptor-deficient (Ldlr−/−) mice with plasma lipid levels distribution similar to hyperlipidemic human subjects as a preclinical animal model test effectiveness atherosclerosis.
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