Causes behind error rates for predictive biomarker testing: the utility of sending post-EQA surveys.

摘要: External quality assessment (EQA) schemes assess the performance of predictive biomarker testing in lung and colorectal cancer have previously demonstrated variable error rates. No information is currently available on underlying causes incorrect EQA results laboratories. Participants by European Society Pathology between 2014 2018 for were contacted to complete a survey if they had at least one analysis or test failure provided cases. Of 791 surveys that sent, 325 completed including data from 185 unique laboratories 514 incorrectly analyzed failed For digital cases immunohistochemistry, majority errors interpretation-related. fluorescence situ hybridization, problems with materials reported frequently. variant analysis, mainly methodological but cancer. Post-analytical (clerical interpretation) more likely detected after release compared pre-analytical analytical issues. Accredited encountered fewer reagent often responded survey. A recent change methodology resulted method-related problems. Testing samples annually introduced personnel lead lower future schemes. Participation improvement projects important reduce deviating laboratories, as different differently affect performance. providers could benefit requesting root cause analyses behind offer even tailored feedback, subschemes,