Fat Mass Accretion from Birth to 5 Years and Metabolic Homeostasis in Childhood: the Healthy Start Study.

摘要: CONTEXT It is unclear how fat mass accretion in early life related to glucose-insulin homeostasis. OBJECTIVE Examine associations of and fat-free from birth childhood with homeostasis a multi-ethnic cohort. METHODS Observational Healthy Start study data collection 2010 2020. Air displacement plethysmography at 4.8 (SD 0.7) years estimated percent (FMP, %), index (FMI, kg/m2), (FFMI, kg/m2). General population recruited academic obstetrics clinics Denver, Colorado, consisting 419 mother/offspring dyads. The main outcome measures were fasting glucose, insulin, model assessment-2 insulin resistance (HOMA2-IR), beta-cell function (HOMA2-B) years. RESULTS Greater was associated higher glucose (ΔFMP β = 0.20 [95% CI 0.06-0.34], ΔFMI 0.90 [0.30-1.50]) participants Hispanic, Black, Other races/ethnicities, while greater non-Hispanic White (ΔFFMI 0.76 [0.21-1.32]). Overall, fat, but not fat-free, also 0.14 [0.09-0.18], 0.71 [0.51-0.92]), HOMA2-IR (FMP 0.02 [0.01-0.02], 0.09 [0.06-0.12]), HOMA2-B 0.92 [0.18-1.36], 4.76 [2.79-6.73]). CONCLUSION infancy shifts children races/ethnicities 5 age. Body composition beginning relevant for metabolic health, precise assessments adiposity pediatric research are needed.