5-aza-2'-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes.
作者： Yu-Bin Ding , Chun-Lan Long , Xue-Qing Liu , Xue-Mei Chen , Liang-Rui Guo
DOI: 10.1371/JOURNAL.PONE.0045364
关键词:
摘要: Background The DNA demethylating agent 5-aza-2′-deoxycytidine (5-aza-CdR) incorporates into and decreases methylation, sparking interest in its use as a potential therapeutic agent. We aimed to determine the effects of maternal 5-aza-CdR treatment on embryo implantation mouse evaluate whether these are associated with decreased levels methyltransferases (Dnmts) three genes (estrogen receptor α [Esr1], progesterone [Pgr], homeobox A10 [Hoxa10]) that vital for control endometrial changes during implantation.
core.ac.uk
harvard.edu
sci-hub.se 参考文章(55)
Shen R, Tao L, Chang S, Gao Jx, Van Brocklyn J, Xu Y, Reversibility of aberrant global DNA and estrogen receptor-alpha gene methylation distinguishes colorectal precancer from cancer. International Journal of Clinical and Experimental Pathology. ,vol. 2, pp. 21- 33 ,(2009)
F. L. Graham, G. F. Whitmore, Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphate. Cancer Research. ,vol. 30, pp. 2636- 2644 ,(1970)
Bruce A Lessey, Wilder A Palomino, KBC Apparao, Steven L Young, Ruth A Lininger, Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women. Reproductive Biology and Endocrinology. ,vol. 4, pp. 1- 10 ,(2006) , 10.1186/1477-7827-4-S1-S9
H Iwase, Y Omoto, H Iwata, T Toyama, Y Hara, Y Ando, Y Ito, Y Fujii, S Kobayashi, DNA methylation analysis at distal and proximal promoter regions of the oestrogen receptor gene in breast cancers British Journal of Cancer. ,vol. 80, pp. 1982- 1986 ,(1999) , 10.1038/SJ.BJC.6690631
Peter Pryzbylkowski, Oluwakemi Obajimi, Judith Clancy Keen, Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR. Breast Cancer Research and Treatment. ,vol. 111, pp. 15- 25 ,(2008) , 10.1007/S10549-007-9751-0
Fahimeh Rahnama, Bridget Thompson, Michael Steiner, Farhad Shafiei, Peter E. Lobie, Murray D. Mitchell, Epigenetic regulation of E-cadherin controls endometrial receptivity. Endocrinology. ,vol. 150, pp. 1466- 1472 ,(2009) , 10.1210/EN.2008-1142
Deepa Sampath, V Ashutosh Rao, William Plunkett, Mechanisms of apoptosis induction by nucleoside analogs Oncogene. ,vol. 22, pp. 9063- 9074 ,(2003) , 10.1038/SJ.ONC.1207229
Stacy Branch, Bettina M. Francis, Cecil F. Brownie, Neil Chernoff, Teratogenic effects of the demethylating agent 5-aza-2'-deoxycytidine in the Swiss Webster mouse Toxicology. ,vol. 112, pp. 37- 43 ,(1996) , 10.1016/0300-483X(96)88183-2
W. Schmahl, P. Török†, H. Kriegel, Embryotoxicity of 5-azacytidine in mice phase- and dose-specificity studies Archives of Toxicology. ,vol. 55, pp. 143- 147 ,(1984) , 10.1007/BF00346054
Masahiro Oka, Amy M Meacham, Takashi Hamazaki, Nemanja Rodić, Lung-Ji Chang, Naohiro Terada, De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine. Oncogene. ,vol. 24, pp. 3091- 3099 ,(2005) , 10.1038/SJ.ONC.1208540