Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis.

摘要: Background Omega-3 fatty acids (FAs) have been suggested as a beneficial supplement in chronic kidney disease (CKD) patients, but the results of randomized clinical trials (RCTs) are controversial. We conducted systematic review and meta-analysis to evaluate all RCTs about impact omega-3 FAs supplementation on cardiometabolic outcomes oxidative stress parameters patients with CKD. Methods performed database search PubMed/MEDLINE, EMBASE, Scopus, Web Science, Cochrane Central, up May 2020. included placebo-controlled that assessed effect any outcomes: blood pressure, total cholesterol (TC), low-density lipoprotein (LDL) high-density (HDL) or triglycerides (TG) parameters. Data were pooled using DerSimonian-Laird's random-effects model. Results Finally, thirteen articles met inclusion criteria for this significantly decrease TC (SMD: -0.26; 95% CI: - 0.51, 0.02; I2 = 52.7%), TG -0.22; 0.43, 36.0%) Malondialdehyde (MDA) levels -0.91; 1.29, 0.54; 00.0%) also increase superoxide dismutase (SOD) 0.58; 0.27, 0.90; Glutathione peroxidase (GPx) 0.50; 0.14, 0.86; activities. However our show no significant effects HDL, LDL pressure. Conclusion This supports current evidence benefit intake improve CKD patients. However, well-designed still needed provide conclusive picture field.