Molecular interdiction of Src-family kinase signaling in hematopoietic cells

摘要: The ability of Src-family kinases (SFKs) to mediate signaling from cell surface receptors in hematopoietic cells is a function their catalytic activity, location and binding partners. Kinase activity regulated the by phosphatases that alter state phosphorylation key tyrosine residues protein partners stabilize kinase active or inactive conformations localize enzyme specific subcellular submembrane domains. can be modulated experimentally through use small molecule inhibitors designed directly target domains regulate altering its acylation.