Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB.

摘要: Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a that transiently associates with the mature nucleolar H/ACA C/D box small ribonucleoproteins (snoRNPs). Several lines of evidence indicate NOLC1 plays an important role in synthesis rRNA biosynthesis ribosomes. In present study, we examined transcriptional regulation mechanisms govern expression NOLC1. We first performed functional dissection promoter. demonstrated transcription factors NF-κB CREB could bind to minimal This was by electrophoretic mobility shift assays chromatin immunoprecipitation. Mutagenesis overexpression revealed positively regulated These findings may provide new insight into regulate expression. [BMB reports 2011; 44(1): 70-75]