Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
作者： Fuwen Yuan , Yu Zhang , Liwei Ma , Qian Cheng , Guodong Li
DOI: 10.1111/ACEL.12602
关键词:
摘要: The nucleolus is a key organelle that responsible for the synthesis of rRNA and assembly ribosomal subunits, which also center metabolic control because critical role ribosomes in protein synthesis. Perturbations biogenesis are closely related to cell senescence tumor progression; however, underlying molecular mechanisms not well understood. Here, we report cellular senescence-inhibited gene (CSIG) knockdown up-regulated NOLC1 by stabilizing 5'UTR mRNA, elevated induced retention NOG1 nucleolus, processing. Besides, expression was negatively correlated with CSIG aged mouse tissue replicative senescent 2BS cells, down-regulation could rescue knockdown-induced senescence. Additionally, decreased human hepatocellular carcinoma (HCC) tissue, ectopic repressed proliferation HCC cells growth xenograft model.
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