Chikungunya virus modulates the miRNA expression patterns in human synovial fibroblasts.
作者： Meghna Agrawal , Neha Pandey , Meghana Rastogi , Smriti Dogra , Sunit K Singh
DOI: 10.1002/JMV.25588
关键词:
摘要: Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes. CHIKV infection leads to polyarthritis and polyarthralgia among patients. The synovial fibroblasts are the primary target for CHIKV. microRNAs (miRNAs) small endogenous noncoding RNAs which posttranscriptionally regulate expression of genes binding their messenger (mRNAs) through 3'-untranslated regions. miRNAs key regulators various pathological processes including viral infection, cancer, cardiovascular disease, neurodegeneration. This study was designed dissect out roles during (Ross Strain E1: A226V) in human fibroblasts. miRNA microarray profiling performed on infected gene prediction analysis, enrichment, network analysis were bioinformatics analyses. subset 26 differentially expressed (DEMs) identified further screened predictions, Gene Ontology, pathway miRNA-mRNA using tools. indicates role DEMs suppressing immune response may contribute persistence Our provides plausible DEMs, miRNAs, mRNA interactions pathways involved molecular pathogenesis
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