Reciprocal Modulation of Sweet Taste by Leptin and Endocannabinoids

摘要: Sweet taste perception is important for animals to detect carbohydrate source of calories and has a critical role in the nutritional status animals. Recent studies demonstrated that sweet responses can be modulated by leptin endocannabinoids [anandamide (N-arachidonoylethanolamine) 2-arachidonoyl glycerol]. Leptin an anorexigenic mediator reduces food intake acting on hypothalamic receptor, Ob-Rb. shown selectively suppress wild-type mice but not receptor-deficient db/db mice. In marked contrast, are orexigenic mediators act via CB1 receptors hypothalamus limbic forebrain induce appetite stimulate intake. peripheral system, also oppose action enhance sensitivities genetically lacking receptors. These findings indicate only regulate central nervous systems may modulate palatability foods altering their cognate