Minimally Invasive versus Open Thymectomy for Thymic Malignancies: Systematic Review and Meta-Analysis

摘要: Complete resection is the standard of care for treatment thymic malignancies. The use minimally invasive surgery remains controversial. We searched online databases and identified studies from 1995 to 2014 that compared open thymectomy Study end points included operative blood loss, time, respiratory complications, cardiac length hospital stay, R0 resection, recurrence. summarized outcomes across using random-effects meta-analysis account study heterogeneity. calculated ORs binary standardized mean differences continuous outcomes. incidence rate ratios number recurrences, accounting total person-time observed in each study. Of 516 potential reference studies, 30 with a 2038 patients met inclusion criteria. Patients Masaoka stage I or II malignancy constituted 94.89% those (MIS) group 78.62% (open) group. Mean tumor size was 4.09 cm versus 4.80 (open). 1355 MIS cases, 32 were converted cases. had significantly less loss; however, no significant operating overall complications identified. Length stay shorter When only analyzed, there difference recurrence rate. One postoperative death occurred results this unadjusted published reports comparing suggest selected malignancy, safe can achieve oncologic similar thymectomy.