Expression of Leptin and Sirtuin-1 is associated with poor prognosis in patients with osteosarcoma
作者： Helin Feng , Peng Guo , Jin Wang , Jianfa Xu , Congcong Xie
DOI: 10.1016/J.PRP.2016.02.002
关键词:
摘要: Sirtuin-1 (SIRT1) is a downstream target of Leptin, and its inhibition promotes p53-mediated apoptosis. This study aimed to evaluate the expression prognostic significance Leptin SIRT1 in osteosarcoma. levels osteosarcoma samples from 89 patients were evaluated by immunohistochemical staining. The correlations between with clinical parameters analyzed Spearman's test Pearson's chi-squared test. Prognostic factors identified Univariate multivariate Cox regression analysis. We found that was low 23.6% 20.2%; moderate 25.8% 24.7%; high 50.5% 55.1% osteosarcoma, respectively. Both significantly associated Enneking stage, distant metastasis neo-adjuvant chemotherapy. correlated they shorter overall survival. Among who received chemotherapy, both survival univariate analysis, but only In conclusion, expressions are patients, significant independent indicator
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