The Role of SIRT1 in Cancer

摘要: In recent years, the importance of histone deacetylases in cancer development has become increasingly apparent. Many nonhistone protein targets have been identified as tumor suppressors or promoters, and aberrant expression regulation therefore shown to either oncogenic protective consequences.1 SIRT1, a member NAD+-dependent class III known Sirtuins, play role not only cancer, but also number other physiological processes health conditions, including metabolic disease, inflammation, neurodegeneration, cardiovascular disease.2, 3 The SIRT1 remains controversial many studies suggested promoter function whereas suppressor this sirtuin.4 In issue American Journal Pathology, Di Sante et al5 weigh on controversy with compelling data supporting status prostate cancer. They used Sirt1−/− mouse model fibroblasts demonstrate against induction intraepithelial neoplasia, increased cellular proliferation, accompanied mitophagy. addition, they that inhibits reactive oxygen species production induces superoxide dismutase 2 activity, TP63 increases loss SIRT1. Here, we discuss implications these findings context current research regarding promoter.