摘要: SIRT1 has been considered as a tumor promoter because of its increased expression in some types cancers and role inactivating proteins that are involved suppression DNA damage repair. However, recent studies demonstrated levels reduced other cancers, deficiency results genetic instability tumorigenesis, while overexpression attenuates cancer formation mice heterozygous for suppressor p53 or APC. Here, I review these findings discuss the possibility activation both extends lifespan inhibits formation.
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