Advances in Treatment of Pediatric Brain Tumors

摘要: The long-term survival of children with brain tumor has improved considerably in the last three decades, owing to advances neuroimaging, neurosurgical, and radiation therapy modalities, coupled application conventional chemotherapy. MRI, MR spectroscopy diffusion-weighted MRI have contributed more accurate diagnosis, prognostication better treatment planning. Neurosurgical been advanced by use functional intraoperative image-guided stereotactic techniques electrophysiologic monitoring. 3-D conformai intensity-modulated therapy, radiosurgery, radiosensitizing agents made safer effective. Conventional chemotherapy, administered either alone or combined quality life tumors. These outcomes also occurred, due, part, their on collaborative national international studies. Recent promising diagnostic therapeutic strategies resulted from understanding molecular biology. Important new approaches include refinement drug-delivery strategies, evaluation biologic markers stratify patients for optimal exploit these differences using “targeted” strategies. blocking cell drug resistance mechanisms, immunotherapy, inhibition signal transduction pathways important tumorigenesis, anti-angiogenic gene therapy. thrust such tumors is especially directed at reducing toxicity improving quality-of-life, as well increasing disease-free survival.