Stem Cells and Progenitor Cells for Tissue-Engineered Solutions to Congenital Heart Defects

作者: Yang Gao , Jeffrey G. Jacot

DOI: 10.4137/BMI.S20058

关键词:

摘要: Synthetic patches and fixed grafts currently used in the repair of congenital heart defects are nonliving, noncontractile, not electrically responsive, leading to increased risk complication, reoperation, sudden cardiac death. Studies suggest that tissue-engineered made from living, functional cells could grow with patient, facilitate healing, help recover function. In this paper, we review research into possible sources cardiomyocytes other cells, including embryonic stem induced pluripotent mesenchymal adipose-derived umbilical cord blood amniotic fluid-derived progenitor cells. Each cell source has advantages, but also technical hurdles overcome, heterogeneity, maturity, immunogenicity, pathogenicity. Additionally, biomaterials as patch materials will need attract support desired induce minimal immune responses.

参考文章(128)
Patrick van Vliet, Teun P. de Boer, Marcel A. G. van der Heyden, Mazen K. El Tamer, Joost P. G. Sluijter, Pieter A. Doevendans, Marie-José Goumans, Hyperpolarization Induces Differentiation in Human Cardiomyocyte Progenitor Cells Stem Cell Reviews and Reports. ,vol. 6, pp. 178- 185 ,(2010) , 10.1007/S12015-010-9142-5
Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin, Daniel Wenzel, Louise S. Bicknell, Matthew E. Hurles, Tessa Homfray, Josef M. Penninger, Andrew P. Jackson, Juergen A. Knoblich, Cerebral organoids model human brain development and microcephaly Nature. ,vol. 501, pp. 373- 379 ,(2013) , 10.1038/NATURE12517
Rebecca Josowitz, Xonia Carvajal-Vergara, Ihor R Lemischka, Bruce D Gelb, Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders. Current Opinion in Cardiology. ,vol. 26, pp. 223- 229 ,(2011) , 10.1097/HCO.0B013E32834598AD
Joseph G. Murphy, Bernard J. Gersh, Douglas D. Mair, Valentin Fuster, Michael D. McGoon, Duane M. Ilstrup, Dwight C. McGoon, John W. Kirklin, Gordon K. Danielson, Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. The New England Journal of Medicine. ,vol. 329, pp. 593- 599 ,(1993) , 10.1056/NEJM199308263290901
Samad Ahadian, Rahaf Rahal, Javier Ramón‐Azcón, Raquel Obregón, Anwarul Hasan, Biomaterials in Tissue Engineering Nature Biotechnology. ,vol. 13, pp. 565- 576 ,(1995) , 10.1038/NBT0695-565
Darryl R. Davis, Eddy Kizana, John Terrovitis, Andreas S. Barth, Yiqiang Zhang, Rachel Ruckdeschel Smith, Junichiro Miake, Eduardo Marbán, Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies Journal of Molecular and Cellular Cardiology. ,vol. 49, pp. 312- 321 ,(2010) , 10.1016/J.YJMCC.2010.02.019
A. van Dijk, H. W. M. Niessen, B. Zandieh Doulabi, F. C. Visser, F. J. van Milligen, Differentiation of human adipose-derived stem cells towards cardiomyocytes is facilitated by laminin Cell and Tissue Research. ,vol. 334, pp. 457- 467 ,(2008) , 10.1007/S00441-008-0713-6
Lior Gepstein, Amira Gepstein, Joseph Itskovitz-Eldor, Dorit Kenyagin-Karsenti, Ofer Binah, Hana Segev, Izhak Kehat, Michal Amit, Erella Livne, Mirit Snir, Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. Journal of Clinical Investigation. ,vol. 108, pp. 407- 414 ,(2001) , 10.1172/JCI12131
Antonio P. Beltrami, Laura Barlucchi, Daniele Torella, Mathue Baker, Federica Limana, Stefano Chimenti, Hideko Kasahara, Marcello Rota, Ezio Musso, Konrad Urbanek, Annarosa Leri, Jan Kajstura, Bernardo Nadal-Ginard, Piero Anversa, Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration Cell. ,vol. 114, pp. 763- 776 ,(2003) , 10.1016/S0092-8674(03)00687-1