Induced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders.
作者： Rebecca Josowitz , Xonia Carvajal-Vergara , Ihor R Lemischka , Bruce D Gelb
DOI: 10.1097/HCO.0B013E32834598AD
关键词:
摘要: PURPOSE OF REVIEW: The development of induced pluripotent stem cell (iPSC) technology has led to many advances in the areas directed differentiation and characterization. New methods for generating iPSC-derived cardiomyocytes provide an invaluable resource study certain cardiovascular disorders. This review highlights current this field, its application thus far genetic disorders RAS/MAPK pathway long-QT syndrome (LQTS), future directions field. RECENT FINDINGS: Enhanced increase efficiency stringently purifying cardiomyocytes. use derived from patients with LEOPARD LQTS shed light on molecular mechanisms disease validated their as reliable human models. SUMMARY: will enable a deeper more applicable understanding disease, well improving our ability achieve successful cell-based therapies. Methods efficiently generate these cells are promise applications technology.
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