Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.
作者： Alessandra Fragale , Marco Tartaglia , Jie Wu , Bruce D. Gelb
DOI: 10.1002/HUMU.20005
关键词:
摘要: … lacks SHP2 binding motifs, blocked the epidermal growth factor-mediated increase in SHP2’… catalytically inactive conformation of SHP2, we performed immune complex protein tyrosine …
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